A systematic review and meta-analysis evaluating the impact of antibiotic use on the clinical outcomes of cancer patients treated with immune checkpoint inhibitors.

Front Oncol · 2023 · PMC10019357 · PMID 36937417

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a clear trendno p-value reported

On the contrary, the suggested deleterious impact of ABX treatment on the ORR did not remain statistically significant (OR 0.78 [95% CI 0.59-1.03]), although a clear trend for an impaired response still persisted.

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highly significantno p-value reported

When excluding HRs calculated from univariate analyses, to keep uniquely cohorts having controlled for confounding factors, the association between ABX and survival outcomes remained very highly significant, with HRs for OS and PFS being respectively of 1.64 [95% CI 1.44-1.90] and 1.62 [1.39-1.89] ( Figures 5 , 6 ).

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