Efficacy of antihyperglycemic therapies on cardiovascular and heart failure outcomes: an updated meta-analysis and meta-regression analysis of 35 randomized cardiovascular outcome trials.

Cardiovasc Diabetol · 2023 · PMC10024854 · PMID 36935489

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showed a trendno p-value reported

In the stratified meta-regression by type of intervention, trials involving intensive glycemic control strategies, DPP-4i, and GLP-1RA showed a trend of reducing the Ln(RR) of MACE in association with a decrease in HbA1c; however, the relationship between HbA1c reduction and MACE risk was not statistically significant for all intervention types (Additional file 1 : Table S4).

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