Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression.

Int J Neuropsychopharmacol · 2023 · PMC10032304 · PMID 36472886

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a strong trendno p-value reported

In contrast, association of IL-6 polymorphism with lifetime depression showed a strong trend in the whole sample and in women.

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highly significantno p-value reported

Results The 3-way interaction including recent stress yielded highly significant results on current depressive symptoms in the UK Biobank sample, which was more pronounced in men and could be replicated on trend level in an independent cohort (NewMood, n = 1638).

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