Integrating microbiome and metabolome revealed microbe-metabolism interactions in the stomach of patients with different severity of peptic ulcer disease.

We found that 89 pathways ( Figure 7D ) were different (P<0.05), and 23 of them were highly significant (P<0.01).

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Based on the above findings, we performed a more in-depth analysis and determined that the two metabolites, Traumatic Acid and hexadecanedioate, showed a trend of HC>ME>PUD in the disease process ( Supplementary Material Table S5 ).

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