Protection from SARS-CoV-2 Variants by MVAs expressing matched or mismatched S administered intranasally to mice.

After challenge, mice that had received the control MVA vector lost ~10 to 20% of their starting weight by day 5; mice immunized with rMVA-W and challenged with CoV-W lost significantly less weight than controls; the mice challenged with CoV-B and -D also lost less weight than controls though there was considerable individual variation and the mean differences did not reach statistical significance (Fig. 2d ).

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