Both fast and slow timescales of cross-correlations increased with the RF-center distance in both monkeys, but the increase in the fast timescale did not reach statistical significance in monkey N ( τ 2 : p < 10 −10 , τ 1 : p G < 10 −10 , p N = 0.36, two-sided Wilcoxon rank-sum test), possibly due to narrower range of RF-center distances in monkey N compared to monkey G (median d RF,N = 0.77, d RF,G = 2.08 dva).
The risk allele G of rs7535263 was also more frequent in cases (allele frequency, 64 of 104 [62%]) of cohort 2 compared with controls (allele frequency, 1451 of 2584 [56%]) but did not reach statistical significance, most likely representing an underpowered comparison (combined meta-analysis (OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10 −8 ) ( Figure 4 ).
Furthermore, treatment with perampanel caused a significantly decreased cell viability only in NCH620, while the reduction observed for NCH645 did not reach statistical significance (NCH620 32.4%, p < 0.0001; NCH645 12.3%, p = 0.135; Figure 2 ). 3.2.
With the HEMI groups, although LIB appeared to induce a slight decrease in reversal learning during both dark phases, these differences did not reach statistical significance upon comparing between the HEMI Sham and Blast groups [Time: F (4.687, 103.2) = 39.35, p < 0.0001; Group: F (1, 30) = 0.2318, p = 0.6337; Time × Group: F (46, 1,380) = 0.4483, p = 0.9995; Subject: F (30,1,380) = 26.52, p < 0.0001]. 3.2 Cognitive flexibility of the reversal learning The main purpose of the reversal learning phase is to evaluate cognitive learning flexibility of the HEMI and NCAR mice.
In addition, in an in vivo experiment including the treatment of non-targeting PG CAR-IL15 T cells, no significant body weight loss was seen in the mice of this group, although we indeed observed a trend toward slower tumor growth in those treated mice from Day 18 after treatment, which did not reach statistical significance (mean tumor volume on Day 21: 39.5 vs 454.1 or 301.7 mm 3 for H9 CAR-IL15 vs UN-T or PG CAR-IL15, p < 0.0001; Figure S4F ); this observation is possibly explained by the fact that IL-15 itself produced from non-activated CAR-T cells may induce the antitumor activity when it accumulates to a certain level, which is consistent with previous studies showing that IL-15 has modest anticancer activity as a single agent ( 24 ).
Weak negative and positive trends were observed between “Junk food” (rho = −0.19, p = 0.003) ( Figure 4 D) and “Beans” (rho = 0.17, p = 0.008) ( Figure 4 E), respectively, and EPA levels, although their p values did not reach statistical significance using the cutoff point of p = 0.00016.
LDL-C tended to be higher but the difference did not reach statistical significance, and HDL-C levels were lower (Mean difference -2.0 mg/dl, 95% CI: -3.1 to -0.9, p = 0.001).
Notably, HBP morphology did not reach statistical significance, while N1 status or higher was a predictor of poor RFS (2.85 (1.50–5.40), p = 0.001) and OS (1.73 (0.79–3.79), p = 0.004), and intrahepatic metastasis was a predictor of poor RFS (2.53 (1.34–4.75), p = 0.004). 4.
Age-Based Analysis of Glycated Hemoglobin Changes in the Continuous Glucose Monitoring-Positive Group When the CGM (+) group was divided into 2 subgroups according to age: <12 years and ≥12 years, the decrease in HbA1c in the younger group did not reach statistical significance, whereas the decrease in the older group was statistically significant ( P < .001) ( Table 2 ).
The same pattern appeared in the other conditions, although it did not reach statistical significance in Condition 2 (Condition 3: odds ratio [OR] = 3.57, CI = 1.59–7.99, p = 0.002, BF = 11.99; Condition 2: OR = 1.15, CI = −2.04 – 2.69, p = 0.753, BF = 0.415; see SOM for more details).
In the cyanotic group, this marker did not reach statistical significance at any evaluated time, while this was reached in the acyanotic group in the pre-CPB sampling (p = 0.002) ( Table 5 ) ( Figure 3 ). 3.4.
Despite showing a trend in this direction, the difference between ∆P TM -based and PCWP-based diastolic stiffness constant β did not reach statistical significance (AUC difference, −0.081; 95% CI, −0.167 to 0.004; P = .003).
Although partial IAB was also more common in COVID-19 patients, this finding did not reach statistical significance ( Figure 1 ). On univariate regression analysis, the presence of COVID-19 infection had a statistically significant association with any degree of IAB (p<0.004), whereas the p-value was >0.05 for all other associations with QTc, QTd and TPe.
Although the differences in pneumothorax and lung hemorrhage rates did not reach statistical significance, we found a significantly higher total complication rate in the HW group than that in the IG group (46.3% vs. 18.9%, p = 0.004).
Although the distribution of the predominant etiologies (AOM or PT) was uneven (Pearson’s chi-square P = 0.047), the differences of other socio-demographic or clinical characteristics between the study cohorts did not reach statistical significance, with the exception of the score of school absenteeism, which was higher in the auto-vaccines cohort (Mann–Whitney’s U test P = 0.004, Table 2 ).
The decreases in the remaining ROIs did not reach statistical significance, but the mean effect across all ROIs indicated that spatial BOLD activity was generally decreased ( t 15 = −3.259, p = 0.005).
For atonic seizures, median percentage change from prerandomization baseline was −33.3% over the entire OLE (IQR = −78.1% to 44.8%, n = 89, p = .2835) and did not reach statistical significance at Months 3, 4–6, or 7–9, but was significantly lower at Months 10–12 (−67.7%; IQR = −97.2% to 24.5%, n = 64, p = .005) and Months 13–15 (−74.8%; IQR = −100.0% to 31.6%, n = 56, p = .0484; Figure 2C ).
The number of healthy follicles was reduced in Androgenized SHAM rats, mean ± SEM of 3.49 ± 0.89, in comparison to Control SHAM rats, 7.6 ± 2.26, but the difference did not reach statistical significance (Student t- test p = 0.006). 3.3 Femur size and weight At Day 180 of life, the Androgenized OVX group exhibited an increased femur weight (mean ± SD) of 1.33 ± 0.24 g compared with the Control OVX, Control SHAM and Androgen SHAM groups, which had weights of 1.17 ± 0.17 g, 1.12 ± 0.11 g and 1.13 ± 0.08, respectively (ANOVA p = 0.04) ( Fig. 1 A).
For linear distance, the reduction in total distance between the knot tying mid- and post-training did not reach statistical significance ( p = 0.007).
Regarding femoral external rotation, the only implant where the observed difference did not reach statistical significance when compared to the native knee was the GCR ( p = 0.007).
However, these differences did not reach statistical significance after the Bonferroni correction ( p > 0.007).
Although the decline in total B cells (CD3 − CD19 + CD20 + ) and naïve B cells (CD3 − CD19 + CD20 + CD27 − CD38 lo ) did not reach statistical significance, mature/activated B cells (CD3 − CD19 + CD20 + CD27 + CD38 moderate ) declined significantly from 313 (267–392) cells/10 5 lymphocytes to 64 (28–166), P = 0.008, and memory B cells (CD3 − CD19 + CD20 + CD27 + CD38 − ) decreased from 608 (380–842) cells/10 5 lymphocytes to 101 (36–200), P = 0.004 (Figure 4 ).
Apart from this association, all other associations did not reach statistical significance ( p > 0.008), and there was no suggestive evidence found at a relaxed significance threshold ( p > 0.05).
We also observed a similar trend for SLF I in the left hemisphere, but the effect did not reach statistical significance when multiple comparisons across tracts were taken into account (t 11 = 3.15, CI = 0.038–0.211, P = 0.009).
During sibutramine therapy, expression of miR-378 in SAT tended to increase but did not reach statistical significance, while in plasma, a reliable increase in the miR-378 level was revealed ( p = 0.01) ( Figure 1 C,D).