Genetic Loss of Sucrase-Isomaltase Function: Mechanisms, Implications, and Future Perspectives.

36 This variant was associated with a lower abundance of Parabacteroides, 36 a genus that is potentially linked to body weight and inflammation, 37 , 38 and with nominally significant altered abundance of certain carbohydrate-digesting genera, including higher abundance of Blautia, 39 a genus that might play a role in metabolic and inflammatory diseases. 40 As the studied European variant only results in a modest reduction in SI activity, the effect of the Arctic-specific complete LoF variant on microbiome composition could potentially be greater.

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