“nominally significant”

In the WHI, all but one of the 1000 cis CpG-transcript pairs from discovery in FHS replicated at a nominally significant p -value of 0.05 with matching effect directionality, while 997 replicated at p < 1E−7 with matching effect directionality.

Although they did not survive false discovery rate correction (FDR) for multiple testing (Additional file 1 : Table S3), the nominally significant pairwise comparisons showed enrichment for π c differences related to hematological and metabolic traits (hematological fold-enrichment = 4.45, p = 2.15 × 10 –7 ; metabolic fold-enrichment = 4.05, p = 4.01 × 10 –6 ).

Nominally significant associations were observed for the following health risk factors: Telomere length was longer among girls compared to boys (p = 3 e–06) and among children of high affluence families (p=0.008).

2.8 EWAS of physical activity and functional analyses At the nominally significant threshold (defined as p < 1 × 10 −5 ), we identified 7 CpGs associated with %time spent in MVPA (Figure 3a and Table S4a ), and 12 CpGs associated with MET‐Hours (Figure 3b and Table S4b ).

Cross-population transferability of loci Of the nominally significant ( p < 1 × 10 −5 ) loci in the short and long sleep duration analyses in the AFR GWAS, none reached even a nominal significance threshold of p < 0.05 in the EUR analysis, and none demonstrate a lower p-value in the cross-population analysis.

After overlapping the pQTL variants with the nominally significant ( P <1 × 10 -5 ) association signals of the GWAS Catalog, they identified that the CD33 protein-related SNP rs1878047 was also associated with BMI.

Only the eQTL for miR-4707-3p (rs2273626) was even nominally significantly associated with expression of its host gene ( HAUS4 ; nominal P = 0.0002), indicating that most of the miR-eQTL identified in this study operate through independent mechanisms.

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

Preliminary examination revealed a nominally significant relationship (B=−0.122, t=−1.91, p=0.057 −2 tailed) in this study, following a priori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity.

Preliminary examination revealed a nominally significant relationship (B = −0.122, t = −1.91, p = 0.057−2 tailed) in this study, following apriori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity (greater than four alleles predicted unspecified drug severity risk).

Among 235 colocalizations with adipose eQTL ( 25 ), 25 (10.6%) also had a nominally significant trait-gene expression association, at an arbitrary P- value threshold of P ≤ 1e−3, despite a sample size of just 859 participants ( Supplementary Table 12 ); 80% of these had consistent effect directions.

At a nominally significant threshold of p-value ≤ 0.001, GWAS analysis discovered 148 MTAs, pointing to 54 QTLs for the coefficient of infection and 179 MTAs for agronomic traits.

Nominally significant DEGs with a p -value < 0.001 were used as the input for the gene set enrichment analyses using FUMA [ 31 ] and ShinyGO version 0.77, as well as for transcription factor binding site enrichment analysis using CiiiDER [ 32 ].

In the non-EA participants (137 cases, 120 controls), rs17538288 remained nominally significant (OR, 2.06; 95% CI, 1.34 to 3.22; P = 0.0012 ) and rs7546189 did not (OR, 1.29; 95% CI, 0.81 to 1.87; P = 0.33 ).

A nominally significant interaction between ACS presentation type (STE-ACS or NSTE-ACS) and the treatment effect on MACEs was found ( p = 0.002).

Nominally significant interactions between LR and HR groups were observed for correlations between YMRS total scores and left superior frontal surface area ( p = 0.002, uncorrected) (Fig. 4A ), CBCL total score and right lateral orbitofrontal surface area ( p = 0.005, uncorrected) (Fig. 4B ), and CBCL dysregulation subscale scores and right lateral orbitofrontal surface area (p = 0.008, uncorrected) (Fig. 4C ).

11 , 12 We observed a nominally significant association with TB risk in both our Chinese Han and Tibetan samples for rs557011 with a consistent direction of effect with reported results ( p = 0.002 and 0.009, respectively).

Although only nominally significant, as endpoints were exploratory, fewer patients experienced an eGFR decline of 30% (HR 0.68; 95% CI 0.58–0.79, P < 0.002), 40% (HR 0.54; 95% CI 0.43–0.67, P < 0.002) or 50% (HR 0.57; 95% CI 0.40–0.81, P < 0.002) to an eGFR < 60 mL/min/1.73 m 2 with dapagliflozin compared with placebo.

Hospitalization The cumulative hospitalization rates were 40.3 per 100 patient-years in the HD group and 33.5 per 100 patient-years in the matched PD group, and this was a nominally significant result (P = 0.002) (Table 3 ).

Although this SNP was also found to be nominally significantly associated with the estimated plasma and effect-site MECs in the present study in the additive model (combined β = −0.07784, nominal p = 0.00232, for the 0–6 h plasma MEC; combined β = −0.07517, nominal p = 0.00310, for the 0–12 h plasma MEC; combined β = −0.09432, nominal p = 0.00250, for the 0–

For tremor, the top scoring model from this subchallenge (yuanfang.gaun) showed only one nominally significant subject (1046, p-value = 0.003), and the cross-subject meta-analysis was not significant after multiple test correction (unadjusted p-value = 0.047).

Examining nominally significant DEGs with a log fold-change (FC) exceeding 1.5 revealed four additional genes, including Depp1 (female-upregulated, logFC 2.3, p < 4 × 10 −3 ) and Avpr1b (female-upregulated, logFC 2.13, p < 2 × 10 −3 ).

Among which tryptophan betaine was the most significant causal metabolite in both AF GWAS data (from Nielsen et al.) (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.76–0.90, P = 9.37 × 10 −6 ) and AF GWAS data (from Roselli et al.) (OR = 0.82, 95% CI = 0.76–0.88, P = 2.00 × 10 −7 ), while uridine was nominally significant metabolites in both AF GWAS data (from Nielsen et al.) (OR = 0.58, 95% CI = 0.40–0.84, P = 0.004) and AF GWAS data (from Roselli et al.) (OR = 0.56, 95% CI = 0.35–0.88, P = 0.01).

However, the G-G haplotype of IRF6 was nominally significant with NSCL/P ( p = 0.0046) and is worthy of consideration for another independent replication study in the future.

Nominally significant associations between eyeAge and both COPD (p-value = 0.0048) and myocardial infarction (p-value = 0.049) were observed ( Supplementary file 3 ).