Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism.

Front Immunol · 2023 · PMC10042232 · PMID 36993973

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did not reach statistical significanceno p-value reported

We found that the immunoproteasome inhibitor (ONX) counteracts the downregulation of Wnt/ ß -catenin signaling pathway genes induced by Pb A-IE although this effect did not reach statistical significance in the case of the Axin2 gene ( Figures 3I–K ).

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