Analysis of gene expression and use of connectivity mapping to identify drugs for treatment of human glomerulopathies.

Front Med (Lausanne) · 2023 · PMC10042326 · PMID 36993805

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 1 × 10 −37actually significant

The Jaccard similarity coefficients and the highly significant p -values (hypergeometric test p < 1 × 10 −37 in all cases) of the overlap of the top upregulated genes in DN and the GNs indicated that upregulated genes were common not only among FSGS, MN and IgAN, but also among DN and the three GNs ( Figure 1B ).

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did not reach statistical significanceno p-value reported

LC3-II tended to be greater with radicicol, but the change did not reach statistical significance.

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may be significantno p-value reported

These results suggest that despite distinct pathogenic mechanisms believed to initiate these GNs, there may be significant commonalities in pathways that are activated to mediate glomerular injury, and common pathways that attenuate injury include the UPR and autophagy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.