trending towards significancep = 0.059
After the creation of the osteochondral fragment, cfDNA concentrations in SF were significantly higher for OA joints than for sham-operated joints on Days 28 (median 1430 and 631, respectively, p = 0.017) and 63 (median 1537 and 606, respectively, p = 0.021); SF concentrations were trending towards significance for OA joints on Days 35 ( p = 0.059) and 56 ( p = 0.070).