The Folic Acid and Creatine Trial: Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population.

Environ Health Perspect · 2023 · PMC10045040 · PMID 36976258

Europe PMC DOI

hedged sentences

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

did not reach statistical significancep = 0.12not close (p > 0.1)

At week 1, the increase in SMI from baseline was greater among participants in the 400FA, 800FA, and creatine treatment arms, with respective within-person changes of 5.4% (95% CI: 2.4, 8.5), 3.0% (95% CI: 0.2, 6.3), and 3.9% (95% CI: 1.4, 6.5) compared with PBO, but it did not reach statistical significance ( p = 0.12 , 0.69, and 0.37, respectively).

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an overall trendno p-value reported

22 However, Figure 3 illustrates that all treatment groups who received FA showed an overall trend toward a decrease in InAs and MMAs concentrations between baseline and week 12 (i.e., a greater proportion of participants falling below the y -axis, representing a decrease in concentrations).

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