Differential Effects of <i>ABCG5/G8</i> Gene Region Variants on Lipid Profile, Blood Pressure Status, and Gallstone Disease History in Taiwan.

Genes (Basel) · 2023 · PMC10047937 · PMID 36981027

Europe PMC DOI

hedged sentences

0.0002

closest p · 0.0× alpha

0.0740

boldest claim

The sentences

borderline significantp = 2.00 × 10 −4actually significant

The rs748096191 genotype also showed significant association with LDL, and non-HDL cholesterol levels and borderline significant association with total cholesterol level after Bonferroni correction ( p = 2.00 × 10 −4 , p = 2.68 × 10 −4 , and p = 8.20 × 10 −4 , respectively).

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showed a trendp = 0.074so close (0.05 < p ≤ 0.1)

Four other variants, which were in nearly complete linkage disequilibrium, exhibited genome-wide significant associations with gallstone disease history, and the ABCG8 rs11887534 variant showed a trend of superiority for gallstone disease history in a nested logistic regression model ( p = 0.074).

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