Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants.

As can be seen in Table 1 , APR-246 showed a trend toward association with doxorubicin, which did not persist with Bonferroni correction, while COTI-2 activity correlated with AZD 6244 (MEK/ERK), cisplatin + gemcitabine, doxorubicin and nitrogen mustard, all of which remained significant after Bonferroni correction.

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