CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration.

As with the TXB4-CD20 fusion, plasma concentration showed a trend toward reduction at the 18 h timepoint, but statistical significance was only reached for TXB4-PD-L1 ( Figure 5 d).

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No correlation was detected for dissociation rate ( Figure 2 c), and a positive trend was observed for affinity (calculated as ratio of dissociation to association rate) and brain penetration ( Figure 2 d).

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