Drug resistance was significantly higher in non-IPD isolates, and serotypes 15A and 35B showed a trend toward multidrug resistance [ 6 ].
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Serotypes and Antibiotic Resistance of <i>Streptococcus pneumoniae</i> before and after the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine for Adults and Children in a Rural Area in Japan.
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The results showed a significant decrease in the PCV13 serotypes in children after the routine PCV13 vaccination ( Table 2 ) and a decreasing trend in adults, although no significant difference was observed ( Table 3 ).