Nevertheless, these studies suggest that the level of passive, non-specific incorporation of reporter proteins and CRISPR/Cas9 into exosomes and microvesicles is quite significant, and should not be neglected when measuring vectorized specific protein loading into EVs or VLPs, which is discussed below.
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Packaging and Uncoating of CRISPR/Cas Ribonucleoproteins for Efficient Gene Editing with Viral and Non-Viral Extracellular Nanoparticles.
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