Due to the CHCHD6 being a mitochondrial gene, there is potential that there may be significant impact of mitochondrial genes or metabolic pathways that are associated with medication non-adherence [ 35 ].
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Heritable Risk and Protective Genetic Components of Glaucoma Medication Non-Adherence.
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Although our study was underpowered for genome-wide significance, SNP rs6474264 within ZMAT4 ( p = 5.54 × 10 –6 ) was found to be nominally significant, with a decreased risk for glaucoma medication non-adherence (OR, 0.22; 95% CI, 0.11–0.42)).