Use of a Preclinical Natural Transmission Model to Study Antiviral Effects of a Carbohydrate-Binding Module Therapy against SARS-CoV-2 in Hamsters.

Levels in the recipient animals receiving Neumifil or vehicle remained similar until day 7, but thereafter appeared to reduce much more rapidly in the Neumifil group, although results did not reach statistical significance ( p > 0.05).

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When the recipient groups were compared, those that received Neumifil had consistently lower clinical scores than those receiving the vehicle ( Figure 2 c), reaching significance 7.4 days post-challenge ( p = 0.0117) and close to significance at 9 days post-challenge ( p = 0.0587).

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