Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging.

Sci Rep · 2023 · PMC10060219 · PMID 36991100

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closest p · 0.3× alpha

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nominally significantp -value = 0.017actually significant

However, results of the enriched Amerindian or African variants’ interaction with APOE -ɛ4 on MCI analysis, the BinomiRare test identified one nominally significant interaction between an African enriched variant, rs8112679, and APOE -ɛ4 on MCI ( p -value = 0.017) (Table 4 ).

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