Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.

A similar trend for genotype effect on spontaneous alternation was observed in the present study, although our results did not reach statistical significance.

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Significant main effects of genotype and/or significant genotype × exposure interactions were found in the cingulate cortex (Cg), primary motor cortex (M1), secondary motor cortex (M2), infralimbic cortex (IL), piriform cortex (Pir), nucleus accumbens shell (AcbSh), dorsal part of the lateral septal nucleus (LSD), lateral hypothalamus (LH), paraventricular nucleus of the thalamus (PVT), CA1, CA3, dorsal DG (dDG), ventral DG (vDG), and ventromedial hypothalamus (VMH), although genotype × exposure interactions were marginally significant in the IL and dDG (Additional file 4 : Table S5). 5-HTT−/− mice showed an increased number of c-Fos-positive cells in the PVT and LH, and a decreased number of c-Fos-positive cells in the Cg, M1, M2, Pir, IL, AcbSh, LSD, CA1, CA3, dDG, vDG, and VMH, after exposure to the forced swim test, compared to 5-HTT+/+ mice (Fig. 6 d–n).

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