Prime editing with genuine Cas9 nickases minimizes unwanted indels.

Nat Commun · 2023 · PMC10063541 · PMID 36997524

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Similar to results from the substitution and insertion experiments, ePE3 (H840A) and ePE3 (H840A + N863A) induced the same frequencies of the correct deletion (on average, 49.6 ± 5.0% and 48.4 ± 5.4%, respectively), but the frequency of unwanted indels induced by ePE3 (H840A + N863A) showed a trend to decrease at the five loci (Fig. 5g and S 7C ).

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