Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays.

In the presence of NS5806 the Ca 2+ -affinity of cChimera is slightly increased with a K d of 1.2 ± 0.2 μmol/L, which however, did not reach statistical significance ( p = 0.07 for an unpaired, two-tailed student’s t-test).

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Quantitative analysis of the chemical shift perturbations (CSPs) shows a cluster of highly significant values in only the C-lobe of cTnC around residues 120–130 (Fig. 4 c, bottom), suggesting that Furamidine does not interact with NcTnC.

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