gene expression scores for schizophrenia To obtain an aggregate measure of transcriptional correlates of schizophrenia for each individual, we created a weighted sum of each individual’s covariate-adjusted gene expression values multiplied by the schizophrenia weights, using only the genes that had nominally significant differential gene expression in schizophrenia (as determined using the second model above).
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Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort.
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