Tau-mediated axonal degeneration is prevented by activation of the Wld^S pathway.

Whether it occurs due to a reduction in tau’s phosphorylation status is unclear as though there was a clear trend for reduced phosphorylation at the two pathological sites we examined (PHF1 ser/thr396 and 40 and AT8 ser202/thr205), this did not reach significance.

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3 ) but became highly significant at the late time points post Wld S pathway activation ( Fig. 7 ).

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