Intraclass correlation analysis for somatic signs showed an estimate for heritability of 0.668 in mecamylamine treated animals and 0.318 in saline treated mice, consistent with the highly significant increase ( p < 0.0001) in somatic signs caused by mecamylamine treatment of nicotine‐exposed mice (11.82) versus saline treatment (3.24).
When phenotypic data from this cocaine trait was correlated with the same basal NAc gene expression data used to assess nicotine withdrawal‐related candidate genes in this study (Table 1B ), a total of nine genes were found to have a nominally significant cocaine phenotype correlation ( p ≤ 0.05, | ρ | ≥ 0.5), were located within the Nic_ptow1 SI, and had significant cis ‐eQTL ( Cbl , Dlat , Fxyd2 , Hyou1 , Ncam1 , Scn4b , Sorl1 , and Ube4a ).