Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets.

c‐Myc staining appears more intense in normal‐weight OA synovial tissue than obese synovium, where there was minimal expression observed in the synovial sublining tissue, as supported by quantitative colocalization analysis, which showed a trend for increased Myc staining in normal‐weight OA, although not significant ( p = .0924) (Figure 5F ).

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