DNA Methylation of POMC and NR3C1-1F and Its Implication in Major Depressive Disorder and Electroconvulsive Therapy.

2 ). POMC DNAm at baseline At baseline, ECT patients showed higher DNAm levels compared with UDC and HC (EMM(±SE): ECT: 0.252( ± 0.013), UDC: 0.156 ( ± 0.015), HC: 0.162( ± 0.014); Fig. 3 ). However, ECT-NR showed a significantly higher baseline POMC m when compared to the control groups (EMM(±SE): NR=0.279(±0.015); UDC=0.162(±0.013); HC=0.168(±0.012); MLM p<0.001), whereas ECT-R just barely missed statistical significance (R: 0.215(±0.018), F(2,811)=2.909, p=0.055).

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