2 ). POMC DNAm at baseline At baseline, ECT patients showed higher DNAm levels compared with UDC and HC (EMM(±SE): ECT: 0.252( ± 0.013), UDC: 0.156 ( ± 0.015), HC: 0.162( ± 0.014); Fig. 3 ). However, ECT-NR showed a significantly higher baseline POMC m when compared to the control groups (EMM(±SE): NR=0.279(±0.015); UDC=0.162(±0.013); HC=0.168(±0.012); MLM p<0.001), whereas ECT-R just barely missed statistical significance (R: 0.215(±0.018), F(2,811)=2.909, p=0.055).
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p=0.051
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Conversely, in the latter half of the study, where the training intervention shifted toward more intense training sessions and CHO intake was reintroduced in the PER group, CHO oxidation at LT and total CHO oxidation returned to baseline levels - although total CHO oxidation barely missed statistical significance ( p = 0.063) - accompanied by a normalization of fat oxidation.
Finally, the mean SCT of 94.6 ± 36.7 was considerably lower in predominantly central EMAP compared to the other three clusters, although this finding barely missed statistical significance ( P = 0.07).
Associations of Taxa With Glaucoma, IOP, and VCDR Nine taxa showed a significantly different abundance in people with glaucoma compared to healthy controls; 16 taxa barely missed statistical significance ( Supplementary Table S2 ).
However, the studies conducted in HFpEF barely missed statistical significance and left a consistent level of uncertainty, possibly in view of the wide heterogeneity of HFpEF phenotypes.
In Vorarlberg, melanoma mortality reduction in the whole study period of 1985–2019, which just barely missed statistical significance, could thus be the result of both interventions during two different time intervals.
The decreased page views, which only barely missed statistical significance, were possibly due to the increasing uncertainty amongst the population, which could have led to the relativization of “lifestyle medicine” like esthetic plastic surgery and information in this regard compared to the potentially life-threatening COVID-19 disease.
The occurrence frequency of microstate B was also greater in the ASD group, although the difference barely missed statistical significance (SMD = 0.45, 95%CI: 0.00–0.90).
EDA3 20056.86 pg/mL, IQR 12573.71–30082.41; median of active progressive MS 19302.28 pg/mL, IQR 17358.62–28659.20; median of active AE 3082.10, IQR 1380.97–12526.44; p = 0.155) showed no significant differences, the cNfL/cGFAP ratio successfully separated AE from stable MS patients and controls but barely missed statistical significance in separating AE from active progressive MS patients (median of controls 0.047, IQR 0.034–0.052; median of MS NEDA3 0.06, IQR 0.04–0.12; median of active progressive MS 0.06, IQR 0.06–0.07; median of active AE 0.406, IQR 0.145–1.037; active AE vs. controls p < 0.001; active AE vs.
Moreover, the task was a key-press laboratory surrogate that omitted movement execution, spatial pressure, and fatigue; accuracy was already near the ceiling; and the critical session-by-stimulation interaction barely missed statistical significance, rendering the finding fragile at best.
We replicated the seemingly unfavorable properties of larger HDL for all-cause mortality by measuring Apo-A2 content in SHIP-START and for CVD mortality for HDL1-C in SHIP-TREND, although the latter association barely missed statistical significance.
Effect of ribitol and ribose treatment on tricarboxylic acid cycle (TCA) The level of citrate was clearly upregulated by both treatments, although the increase by ribose treatment barely missed statistical significance (Fig. 3 ).
Regarding the outcome CKD, we found significant positive associations between overt hypothyroidism and eGFR using FAS, while the association between overt hyperthyroidism and eGFR using CKD-EPI barely missed statistical significance.
Although upregulation of FASN, GLUD1, and G6PD in the high-risk group barely missed statistical significance, these enzymes deserve attention given their biological significance in cancer and metabolism ( Figure 3 , Table S3 ).