The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.

Elife · 2023 · PMC10072880 · PMID 36799304

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However, consistent with our hypothesis, mice treated with Elam or NMN showed a trend for reduction of ROS-associated G→T/C→A and G→C/C→G mutations in heart, kidney, liver, and skeletal muscle.

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