Investigating the efficacy and safety of calcipotriol/betamethasone dipropionate foam and laser microporation for psoriatic nail disease-A hybrid trial using a smartphone application, optical coherence tomography, and patient-reported outcome measures.

AFL pretreatment had no statistically significant effect on the Cal/BD foam treatment response (see Figure S3 ) but showed a positive trend in clinical improvement (+19.3% reduction in median N‐NAIL score, p = 0.62; +20.0% reduction in median NAPSI score, p = 0.45).

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AFL‐assisted Cal/BD treatment led to higher clinical (N‐NAIL −85%, NAPSI −78%) and OCT‐assessed (−46%) reduction of PND signs than Cal/BD alone (N‐NAIL −66%, NAPSI −58%, OCT −37%), but did not reach statistical significance.

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