SARS-CoV-2 <i>ORF3A</i> interacts with the Clic-like chloride channel-1 (<i>CLCC1</i>) and triggers an unfolded protein response.

CLCC1 knockdown alone caused an increase in spliced XBP1 expression that did not reach statistical significance ( p = 0.0786) ( Fig. 4F ), showing another homeostatic UPR gene that was not further upregulated by ORF3A expression in the setting of CLCC1 knockdown.

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