Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease: The ESSENCE-2 Randomized Clinical Trial.

JAMA Ophthalmol · 2023 · PMC10080403 · PMID 37022717

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did not reach statistical significanceno p-value reported

This compound itself provides considerable improvement in dry eye signs and symptoms, 15 potentially providing an explanation as to why the treatment effects in symptoms did not reach statistical significance in the overall population.

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