Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study.

identified nominally significant cross-sectional associations between IEAA and eGFR in their recent multi-ancestry meta-analyses [ 13 ].

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Results Summary-level MR of EAA on kidney function In the summary-level MR analysis, significant and marginally significant associations were identified between genetically predicted EAA and both eGFR and CKD (Fig. 2 A, Table 1 ).

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S1) as well as pleiotropy-robust methods, where similar effect sizes with at least marginal significance in both weighted median and MR-PRESSO analyses were observed (Additional file 1 : Table S7 and S8).

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