Extensive Peritonectomy is an Independent Risk Factor for Cisplatin HIPEC-Induced Acute Kidney Injury.

Increasing the applied cisplatin dose to 150 mg/m 2 , yielding a higher CDDP perfusate concentration of 75 mg/L instead of 37.5 mg/L (Table 1 : concentration experimental group), increased cisplatin absorption to 9.5 ± 1.7%, 12.2 ± 2.2%, and 14.3 ± 2.4%, respectively, but this difference did not reach statistical significance (Fig. 4 A).

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