Comparison of the efficacy and safety of picosecond Nd:YAG laser (1,064 nm), picosecond alexandrite laser (755 nm) and 2% hydroquinone cream in the treatment of melasma: A randomized, controlled, assessor-blinded trial.

Melasma area and severity index scores All three groups showed a trend toward improvement of the MASI score, even after the end of interventions ( Figure 3 ).

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However, mMASI or hemi-MASI displayed an increasing trend in the later stages of follow-up in the two studies mentioned above ( 21 , 31 ), suggesting a likelihood of melasma recurrence after a period of cessation of treatment.

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