Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain.

J Headache Pain · 2023 · PMC10088116 · PMID 37038131

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did not reach statistical significanceno p-value reported

1 D), whereas the level of 2-AG, which was already naturally high, had an ambiguous apparent increase in some animals, but this did not reach statistical significance (Fig. 1 E).

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