Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity.

Using a previously described protocol ( Methods ) to evoke the M-current, we observed a trend toward a decrease in M-current and current density in DRG neurons treated with IM relative to control condition, though these differences did not reach statistical significance ( Fig. 2 C and D ) ( P = 0.14 and 0.10, respectively).

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