How resistant are levodopa-resistant axial symptoms? Response of freezing, posture, and voice to increasing levodopa intestinal infusion rates in Parkinson disease.

Despite a small trend in postural angles, our study suggests that other axial symptoms like postural abnormalities and speech impairment cannot be satisfactorily improved (at least acutely) by increasing the levodopa dose in patients with already adequate control of motor symptoms and fluctuations.

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A trend of improvement between T1 and T3 was found for gait speed and double support during the 2MWT, for turn angle during the TUG test, and for turn velocity during the 360° Turn Test; step duration during the 2MWT, sit to stand duration during the TUG test, sway area, and acceleration showed a trend of worsening without reaching statistical significance (Table 3 ).

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