Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the myocardium of mice after myocardial infarction.

Phytother Res · 2023 · PMC10092487 · PMID 36218220

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Compared with the MI model group, the number of CD4 + Foxp3 + Treg cells was significantly increased in the heart ( p < .05), spleen ( p < .05) and LNs ( p < .05) of mice treated with BBR, and the number of CD4 + ROR‐γt + Th17 cells in the heart showed a trend of decrease but there was no significant difference (Figure 2c , S1d ).

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