Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials.

Comparing the two different LTMT regimes O-TIE ( n = 71) and CYC/VBL ( n = 18), patients receiving CYC/VBL showed a tendency towards better EFS and OS of 60% (95% CI, 40 to 88%) and 70% (95% CI, 52 to 96%), respectively, compared to those receiving O-TIE (EFS, 36% (95% CI, 26 to 49%); OS, 48% (95% CI, 38 to 62%)), although these differences did not reach statistical significance (OS p = 0.08, EFS p = 0.09) ( Figure 4 ).

also in 111,027 other papers