The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes.

Int J Mol Sci · 2023 · PMC10095080 · PMID 37047737

Europe PMC DOI

hedged sentence

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

did not reach statistical significancep = 0.077so close (0.05 < p ≤ 0.1)

lation by acid alone ( Figure 3 , Supplemental Table S3 ) Treatment with 10 μM amprenavir led to statistically significant reductions in pH4 pepsin-mediated induction of MMP1 ( p = 0.0006), MMP7 ( p = 0.043), MMP9 ( p = 0.0066), and MMP14 ( p = 0.034), as well as a reduction in MMP2 expression that did not reach statistical significance ( p = 0.077).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.