Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study.

For atonic seizures, median percentage change from prerandomization baseline was −33.3% over the entire OLE (IQR = −78.1% to 44.8%, n = 89, p = .2835) and did not reach statistical significance at Months 3, 4–6, or 7–9, but was significantly lower at Months 10–12 (−67.7%; IQR = −97.2% to 24.5%, n = 64, p = .005) and Months 13–15 (−74.8%; IQR = −100.0% to 31.6%, n = 56, p = .0484; Figure 2C ).

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