Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment.

Although we observed only four nominally significant interactions between prenatal exposures and sex on obesity, we revealed a prenatal environment defined by specific levels of these exposures whose effect on obesity strongly changed between sexes, with a 93% reduction in obesity risk for girls in relation to boys (OR interaction = 0.070, P = 2.59 × 10 −5 ).

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We thus created an average environment with highly significant female protection against obesity, which hereinafter we will refer to it as E1.

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