Immune cells and their related genes provide a new perspective on the common pathogenesis of ankylosing spondylitis and inflammatory bowel diseases.

A clear trend is that up-regulated coDEGs were firmly associated with neutrophils, while down-regulated genes are significantly associated with CD8+ T−cells and CD4+ T−cells in both AS and IBD datasets. 3.5 Key immune-cell-related CoDEGs The up-regulated gened associated immune cells were neutrophils, while the down-regulated gene associated cells were CD4+ and CD8+ T cells, which were the most significant cells in the correlation analysis.

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