Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.

In old female β-actin–Cre +/– p16-LOX-ATTAC mice, the results were similar ( Supplemental Figure 12 , A–O); however, improvements in response to AP treatment did not reach statistical significance (i.e., using parametric statistics) for trabecular BV/TV at the spine ( Supplemental Figure 12L ; Student’s t test P = 0.070; Wilcoxon rank-sum test P = 0.065) or trabecular BV/TV at the femur ( Supplemental Figure 12M ; Student’s t test P = 0.138; Wilcoxon rank-sum test P = 0.034) because of the suboptimal statistical power as a result of higher-than-anticipated numbers of deaths in the aged β-actin–Cre +/– p16-LOX-ATTAC cohort.

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This assay revealed a highly significant accumulation of Sn osteocytes with aging in old (24 months old) compared with young adult (6 months old) mice ( Figure 1, C–E ).

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