EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.

Trials · 2023 · PMC10105400 · PMID 37061693

Europe PMC DOI

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highly significantno p-value reported

A subsequentially conducted randomized controlled bi-center trial (Hannover and Bonn) in 20 vs 20 patients found a highly significant reduction in NE in the treatment group within 6 h compared to the SOC group (2).

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showed a trendno p-value reported

The largest of those trials showed a trend towards improved survival [ 8 ].

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