Randomized prospective trial to detect and distinguish between medication nonadherence, drug-drug interactions, and disease progression in chronic cardiometabolic disease.

Disease progression Although making the diagnosis of disease progression trended in the right direction for these patient cases at + 3.2%— this trend did not reach statistical significance (p = 0.838) and, in the difference-in-difference estimation, the intervention group was 0.3x as likely to diagnose disease progression and 0.3x as likely to advance the medication regimen or increase medication dose.

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