Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Psychol Med · 2023 · PMC10106286 · PMID 37310336

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

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boldest claim

The sentences

trending towards significancep = 0.058so close (0.05 < p ≤ 0.1)

In secondary analysis of the current study, PRS-Sz was associated with depressive and positive sub-domains of the CAPE-42 in the IMAGEN cohort, whereas in the older Utrecht cannabis cohort, PRS-Sz was associated with depressive and negative sub-domains, with results trending towards significance for the positive sub-domain ( p = 0.058).

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