Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands.

Overall, a clear trend can be delineated on the basis of these data: ( i ) the C -terminal methyl amide determines the CB1 agonist activity of t Leu-containing compounds preserving the p -Cl substitution on the phenyl ring and pyrrole moiety on C5 (e.g., 32 and 34 ); ( ii ) the N -methyl amide function causes the shift o

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